| # | Squadra | PG | V | P | S | GF | GC | DG | Pts. |
|---|---|---|---|---|---|---|---|---|---|
| 1 | New England | 17 | 11 | 3 | 3 | 33 | 21 | +12 | 36 |
| 2 | Orlando City | 16 | 8 | 4 | 4 | 26 | 21 | +5 | 28 |
| 3 | Nashville SC | 16 | 6 | 9 | 1 | 25 | 15 | +10 | 27 |
| 4 | New York City | 15 | 8 | 2 | 5 | 30 | 16 | +14 | 26 |
| 5 | Philadelphia Union | 17 | 6 | 7 | 4 | 21 | 17 | +4 | 25 |
| 6 | Columbus Crew | 16 | 6 | 6 | 4 | 17 | 16 | +1 | 24 |
| 7 | Montréal | 16 | 6 | 4 | 6 | 21 | 20 | +1 | 22 |
| 8 | D.C. United | 16 | 6 | 3 | 7 | 21 | 18 | +3 | 21 |
| 9 | New York RB | 15 | 5 | 3 | 7 | 20 | 20 | +0 | 18 |
| 10 | Toronto | 16 | 3 | 5 | 8 | 21 | 33 | -12 | 14 |
| 11 | Cincinnati | 15 | 3 | 5 | 7 | 17 | 29 | -12 | 14 |
| 12 | Atlanta United | 16 | 2 | 8 | 6 | 16 | 21 | -5 | 14 |
| 13 | Chicago Fire | 16 | 3 | 4 | 9 | 18 | 28 | -10 | 13 |
| 14 | Inter Miami | 14 | 3 | 3 | 8 | 12 | 24 | -12 | 12 |
| 2021. Agosto 5. giovedì | ||
| New England | 00:00 | Nashville SC |
| Columbus Crew | 00:30 | D.C. United |
| Philadelphia Union | 00:30 | Toronto |
| Montréal | 00:30 | Atlanta United |
| Orlando City | 01:00 | Inter Miami |
| Chicago Fire | 01:00 | New York City |
| New York RB | 01:00 | Cincinnati |
| Austin | 02:00 | Houston Dynamo |
| Seattle Sounders | 03:00 | Dallas |
| Los Angeles | 03:30 | Sporting KC |
| Portland Timbers | 03:30 | SJ Earthquakes |
| LA Galaxy | 03:30 | Real Salt Lake |
| 2021. Agosto 8. domenica | ||
| Cincinnati | 00:30 | Orlando City |
| Columbus Crew | 00:30 | Atlanta United |
| Toronto | 01:00 | New York City |
| Minnesota United | 01:00 | Houston Dynamo |
| Dallas | 01:30 | Austin |
| Colorado Rapids | 02:00 | Sporting KC |
| Portland Timbers | 03:30 | Real Salt Lake |
| 2021. Agosto 2. lunedì | ||
| Toronto | 1 - 1 | Nashville SC |
| 2021. Agosto 1. domenica | ||
| Philadelphia Union | 1 - 1 | Chicago Fire |
| Vancouver Whitecaps FC | 2 - 2 | Minnesota United |
| Austin | 0 - 1 | Colorado Rapids |
| Sporting KC | 1 - 2 | Dallas |
| Houston Dynamo | 0 - 0 | Real Salt Lake |
| Inter Miami | 2 - 1 | Montréal |
| Cincinnati | 0 - 0 | D.C. United |
| 2021. Luglio 31. sabato | ||
| New York RB | 2 - 3 | New England |
| Seattle Sounders | 0 - 1 | SJ Earthquakes |
| LA Galaxy | 4 - 1 | Portland Timbers |
| Orlando City | 3 - 2 | Atlanta United |
| New York City | 4 - 1 | Columbus Crew |
| 2021. Luglio 29. giovedì | ||
| Los Angeles | 2 - 2 | Minnesota United |
| 2021. Luglio 26. lunedì | ||
| Seattle Sounders | 1 - 3 | Sporting KC |
| D.C. United | 1 - 0 | New York RB |
| Inter Miami | 1 - 1 | Philadelphia Union |
| 2021. Luglio 25. domenica | ||
| New England | 2 - 1 | Montréal |
| New York City | 5 - 0 | Orlando City |
