| # | Squadra | PG | V | P | S | GF | GC | DG | Pts. |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 29 | 17 | 8 | 4 | 47 | 33 | +14 | 59 |
| 2 | Orlando City | 29 | 14 | 8 | 7 | 45 | 36 | +9 | 50 |
| 3 | Columbus Crew | 29 | 14 | 6 | 9 | 60 | 41 | +19 | 48 |
| 4 | Philadelphia Union | 28 | 14 | 6 | 8 | 51 | 35 | +16 | 48 |
| 5 | New England | 28 | 13 | 9 | 6 | 47 | 34 | +13 | 48 |
| 6 | Atlanta United | 30 | 12 | 10 | 8 | 57 | 46 | +11 | 46 |
| 7 | Nashville SC | 28 | 12 | 7 | 9 | 35 | 27 | +8 | 43 |
| 8 | Montréal | 29 | 11 | 4 | 14 | 29 | 41 | -12 | 37 |
| 9 | D.C. United | 30 | 9 | 9 | 12 | 38 | 39 | -1 | 36 |
| 10 | New York City | 30 | 7 | 13 | 10 | 30 | 36 | -6 | 34 |
| 11 | Chicago Fire | 29 | 8 | 9 | 12 | 32 | 45 | -13 | 33 |
| 12 | Charlotte | 28 | 7 | 12 | 9 | 36 | 45 | -9 | 33 |
| 13 | Inter Miami | 28 | 9 | 4 | 15 | 36 | 44 | -8 | 31 |
| 14 | New York RB | 29 | 7 | 10 | 12 | 25 | 34 | -9 | 31 |
| 15 | Toronto | 29 | 4 | 10 | 15 | 24 | 45 | -21 | 22 |
| 2023. Settembre 24. domenica | ||
| Atlanta United | 00:30 | Montréal |
| Cincinnati | 00:30 | Charlotte |
| D.C. United | 00:30 | New York RB |
| New York City | 00:30 | Toronto |
| Philadelphia Union | 00:30 | Los Angeles |
| Chicago Fire | 01:30 | New England |
| Dallas | 01:30 | Columbus Crew |
| Sporting KC | 01:30 | Houston Dynamo |
| Minnesota United | 01:30 | St. Louis City |
| Real Salt Lake | 02:30 | Vancouver Whitecaps FC |
| Portland Timbers | 03:30 | Colorado Rapids |
| SJ Earthquakes | 03:30 | Nashville SC |
| 2023. Settembre 25. lunedì | ||
| Orlando City | 00:30 | Inter Miami |
| Austin | 02:30 | LA Galaxy |
| 2023. Settembre 28. giovedì | ||
| Philadelphia Union | 00:30 | Dallas |
| Colorado Rapids | 02:30 | Vancouver Whitecaps FC |
| 2023. Settembre 21. giovedì | ||
| Portland Timbers | 2 - 1 | SJ Earthquakes |
| LA Galaxy | 4 - 3 | Minnesota United |
| Real Salt Lake | 1 - 3 | Dallas |
| Colorado Rapids | 1 - 2 | Seattle Sounders |
| St. Louis City | 0 - 0 | Los Angeles |
| Sporting KC | 0 - 3 | Nashville SC |
| Houston Dynamo | 4 - 1 | Vancouver Whitecaps FC |
| D.C. United | 1 - 1 | Atlanta United |
| Charlotte | 2 - 2 | Philadelphia Union |
| Columbus Crew | 3 - 0 | Chicago Fire |
| Inter Miami | 4 - 0 | Toronto |
| Montréal | 1 - 1 | Cincinnati |
| New York RB | 1 - 1 | Austin |
| New York City | 2 - 0 | Orlando City |
| 2023. Settembre 18. lunedì | ||
| Austin | 1 - 2 | Portland Timbers |
