| # | Squadra | PG | V | P | S | GF | GC | DG | Pts. |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Atlanta United | 0 | 0 | 0 | 0 | 0 | 0 | +0 | 0 |
| 2 | Chicago Fire | 0 | 0 | 0 | 0 | 0 | 0 | +0 | 0 |
| 3 | Cincinnati | 0 | 0 | 0 | 0 | 0 | 0 | +0 | 0 |
| 4 | Columbus Crew | 0 | 0 | 0 | 0 | 0 | 0 | +0 | 0 |
| 5 | D.C. United | 0 | 0 | 0 | 0 | 0 | 0 | +0 | 0 |
| 6 | Inter Miami | 0 | 0 | 0 | 0 | 0 | 0 | +0 | 0 |
| 7 | Montréal | 0 | 0 | 0 | 0 | 0 | 0 | +0 | 0 |
| 8 | Nashville SC | 0 | 0 | 0 | 0 | 0 | 0 | +0 | 0 |
| 9 | New England | 0 | 0 | 0 | 0 | 0 | 0 | +0 | 0 |
| 10 | New York City | 0 | 0 | 0 | 0 | 0 | 0 | +0 | 0 |
| 11 | New York RB | 0 | 0 | 0 | 0 | 0 | 0 | +0 | 0 |
| 12 | Orlando City | 0 | 0 | 0 | 0 | 0 | 0 | +0 | 0 |
| 13 | Philadelphia Union | 0 | 0 | 0 | 0 | 0 | 0 | +0 | 0 |
| 14 | Toronto | 0 | 0 | 0 | 0 | 0 | 0 | +0 | 0 |
| 2021. Aprile 17. sabato | ||
| Houston Dynamo | 01:00 | SJ Earthquakes |
| Seattle Sounders | 02:30 | Minnesota United |
| Montréal | 19:00 | Toronto |
| Orlando City | 20:00 | Atlanta United |
| Los Angeles | 23:00 | Austin |
| 2021. Aprile 18. domenica | ||
| Dallas | 01:00 | Colorado Rapids |
| New York RB | 01:00 | Sporting KC |
| D.C. United | 01:00 | New York City |
| Nashville SC | 01:30 | Cincinnati |
| Chicago Fire | 01:30 | New England |
| Inter Miami | 20:00 | LA Galaxy |
| Columbus Crew | 22:30 | Philadelphia Union |
| 2021. Aprile 19. lunedì | ||
| Vancouver Whitecaps FC | 03:00 | Portland Timbers |
| 2021. Aprile 24. sabato | ||
| Sporting KC | 00:30 | Orlando City |
| New York City | 18:00 | Cincinnati |
| Nashville SC | 19:00 | Montréal |
| Toronto | 20:00 | Vancouver Whitecaps FC |
| SJ Earthquakes | 20:30 | Dallas |
