| # | Squadra | PG | V | P | S | GF | GC | DG | Pts. |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Montréal | 11 | 6 | 2 | 3 | 22 | 19 | +3 | 20 |
| 2 | Orlando City | 12 | 6 | 2 | 4 | 14 | 15 | -1 | 20 |
| 3 | Philadelphia Union | 11 | 5 | 5 | 1 | 16 | 9 | +7 | 20 |
| 4 | Cincinnati | 12 | 6 | 1 | 5 | 16 | 18 | -2 | 19 |
| 5 | New York RB | 11 | 5 | 4 | 2 | 17 | 9 | +8 | 19 |
| 6 | New York City | 10 | 5 | 2 | 3 | 21 | 10 | +11 | 17 |
| 7 | Atlanta United | 11 | 4 | 3 | 4 | 17 | 16 | +1 | 15 |
| 8 | D.C. United | 10 | 4 | 1 | 5 | 14 | 15 | -1 | 13 |
| 9 | Charlotte | 12 | 4 | 1 | 7 | 10 | 15 | -5 | 13 |
| 10 | Columbus Crew | 11 | 3 | 4 | 4 | 15 | 13 | +2 | 13 |
| 11 | New England | 11 | 3 | 3 | 5 | 18 | 20 | -2 | 12 |
| 12 | Toronto | 12 | 3 | 2 | 7 | 16 | 23 | -7 | 11 |
| 13 | Inter Miami | 11 | 3 | 2 | 6 | 11 | 21 | -10 | 11 |
| 14 | Chicago Fire | 11 | 2 | 4 | 5 | 8 | 13 | -5 | 10 |
| 2022. Maggio 19. giovedì | ||
| D.C. United | 00:30 | New York City |
| New York RB | 00:30 | Chicago Fire |
| Philadelphia Union | 00:30 | Inter Miami |
| Minnesota United | 01:00 | LA Galaxy |
| Houston Dynamo | 01:30 | Seattle Sounders |
| Sporting KC | 01:30 | Colorado Rapids |
| Nashville SC | 01:30 | Montréal |
| Vancouver Whitecaps FC | 03:00 | Dallas |
| Los Angeles | 03:30 | Austin |
| SJ Earthquakes | 03:30 | Portland Timbers |
| 2022. Maggio 21. sabato | ||
| Columbus Crew | 20:30 | Los Angeles |
| D.C. United | 21:00 | Toronto |
| Cincinnati | 23:00 | New England |
| 2022. Maggio 22. domenica | ||
| Nashville SC | 00:30 | Atlanta United |
| Montréal | 21:00 | Real Salt Lake |
| Charlotte | 22:00 | Vancouver Whitecaps FC |
| New York City | 22:00 | Chicago Fire |
| 2022. Maggio 15. domenica | ||
| Seattle Sounders | 3 - 1 | Minnesota United |
| Atlanta United | 2 - 2 | New England |
| LA Galaxy | 1 - 3 | Dallas |
| Portland Timbers | 7 - 2 | Sporting KC |
| Real Salt Lake | 2 - 1 | Austin |
| Inter Miami | 2 - 2 | D.C. United |
| Houston Dynamo | 2 - 0 | Nashville SC |
| Chicago Fire | 1 - 2 | Cincinnati |
| Philadelphia Union | 1 - 1 | New York RB |
| Vancouver Whitecaps FC | 3 - 3 | SJ Earthquakes |
| New York City | 2 - 0 | Columbus Crew |
| Charlotte | 0 - 2 | Montréal |
| 2022. Maggio 14. sabato | ||
| Colorado Rapids | 2 - 0 | Los Angeles |
| Toronto | 0 - 1 | Orlando City |
| 2022. Maggio 9. lunedì | ||
| Austin | 0 - 1 | LA Galaxy |
